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✅ — AMD Instinct MI250X Can Run Claude Opus 4.1

The AMD Instinct MI250X packs 128GB VRAM. Claude Opus 4.1 needs ~110GB. You're good to go.

✅ Plenty of headroom

AMD Instinct MI250X can run it — buy or rent

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Hardware Specs

GPU
AMD Instinct MI250X
VRAM
128 GB
Bandwidth
3200 GB/s
MSRP
$12,000

Model Requirements

Model
Claude Opus 4.1
Parameters
200B
VRAM (Q4)
~110 GB
Context
200,000

Estimated Performance

24 tok/s
Estimated inference speed (Q4 quantization)

Pricing

MSRP: $12,000

Claude Opus 4.1 Details AMD Instinct MI250X Specs

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